| Objective:To investigate the efficacy of fibrin glue and dexamethasone preventing readhension and recovering function after decompression in chronic nerve compression model in rat.Method: A Machinnonic's method was used to create a chronic nerve compression model using the sciatic nerve of rats. 72 male Wister rats were randomly divided into four groups: fibrin glue and dexamethasone (FG) group, limethason group, dexamethasone group and control group after decompression. Sciatic nerve index (SCI), motor nerve conduction velocity (MNCV), active potential latency (Lan), gross appearance, light microscopic observation were performed at 4, 8, 12 weeks and electron microscopic observation and morphometric analysis were performed at 12 weeks after operation.Results: The MNCV, SCI, myelineted axons counts, mean axon diameters and mean myeline sheath thickness were significantly better in FG group than those in limethason group, dexamethasone group and control group.Conclusion: Fibrin glue can be used as a carrier for dexamethasone to prevent readhension and improve the regenerating nerve both in its structural and functional recovery. |
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