Effects Of Caspase-3 And Bcl-2 In Myocardial Cell Apoptosis In Hypothyroidism Rats And The Relationship Between The Thyroid Function And Them

Objective: To study the expression of the effecter molecule of myocardial cell apoptosis(Caspase-3) and the resisting apoptosis protein (Bcl-2) in hypothyroidism rats, revealed the pathology of occurrence and development of the myocardial injury in hypothyroidism and the function of the apoptosis on the hypothyroidism heart disease and the intervention effects of Levothyroxine Sodium and stopping giving propylthiouracil. And rectifying the thyroid function quickly and slowly had different influence on the myocardial apoptosis and the myocardial injury resuming or not.Methods: The model of hypothyroidism rats was made by giving them propylthiouracil. Since the rats were given propylthiouracil for 8 weeks, the rats were divided into 3 groups which were giving propylthiouracil (B₁ group), stopped giving propylthiouracil (B₂ group) and giving Levothyroxine Sodium (B₃ group). The pathology condition of the control group, hypothyroidism group and intervention group (B₂ group and B₃ group) was observed in week 3, 6, 8, 10 and 12.The presence of myocardial apoptosis cell was demonstrated by the method of terminal deoxynucleotidyl transferase mediated dTUP nick end...