Association Of The AHSG But Not The IL-6 Promoter Polymorphism With Genetic Susceptibility To Ⅳ Endometriosis

Objective: The etiology and pathogenesis of endometriosis is still unclear. The results of epidemiological family studies and environmental investigations mean endometriosis can be considered as a multifactorial disease with a possible genetic predisposition and with the involvement of environmental toxins. Indeed, genetic analysis revealed a correlation of the disorder with common polymorphisms in low-penetrance genes coding for enzymes responsible for the metabolism of a broad range of xenobiotics and arcinogens. Moreover, isolated reports indicate genetic variants of genes involved in hormone response as all plausible risk factors. Thus far, little is known about other candidate genes involved.α2-Heremans Schmidt glycoprotein (AHSG), which is present at high levels in serum, is a human plasma glycoprotein secreted by the liver. AHSG is a member of the cystatin superfamily of the group of negative acute phase proteins, and it is likely that AHSG participates in the in vitro growth of human cells. Recently, it has been demonstrated that the AHSG gene is expressed in the endometrium of the patients with endometriosis, and that these patients have high levels of AHSG in serum and peritoneal fluid, and significant antibodies...