The Influence Of Angiotensin-converting Enzyme Gene, Glycaemic Control And Their Interaction On Plasma Lipid Levels In Type 2 Diabetes Mellitus

Objective: It has been verified in a number of clinical and experimental studies that type 2 diabetic patients have dyslipidemia as well as hyperglycaemia. The characteristics of dyslipidemia in type 2 diabetic patients is hypertriglyceridemia(HTG), almost normal low density lipoprotein cholesterol(LDL-C), lower high density lipoprotein cholesterol(HDL-C), small dense low density lipoprotein cholesterol and high density lipoprotein cholesterol and postprandial hyperlipidemia. All these changes in plasma lipid and lipoprotein play a key role in the occurrence and development of macro-vascular complications in diabetes mellitus. More than 90% diabetic patients belong to type 2 diabetic patients. So, investigating the pathogenesis of dyslipidemia in type 2 diabetic patients has important clinical signifance.It is believed in recent studies that diabetes mellitus(DM) is a metabolism disorder syndrome, which is characterized by insulin resistance(IR) and companied with dyslipidemia, hypertension, obesity and hyperglycaemia, of wich insulin resistance is the basic pathogenesis of metabolism disorder.