Serial Measurement Of Vascular Endothelial Growth Factor In Serum Of Acute Intracerebral Hemorrhage And Association Between VEGF And Tumor Necrosis Factor Alpha And C-reactive Protein

Objective: 1.To further reveal VEGF participate in the pathophysiological process and its dynamical change rule by serially measuring the levels of VEGF after ICH. 2. Further explore the correlation between brain damage and inflammation, and study the brain injury mechanisms after ICH. 3. To research the correlation between VEGF and TNF-alpha and CRP may help us to find new ways and methods for the treatment of ICH.Methods: 1. ICH group: 30 cases fulfilled the select and exclude criteria: hospitalized within 24 hours, coincidence the criteria specified in the fourth cerebrovascular disease National Academic Conference diagnostic criteria, exclude such as acute and chronic inflammatory diseases, tumors, cerebrovascular malformations, Clotting disorder, skull trauma, stroke caused by neoplasms, mixed stroke, haemorrhagic infarct, et al. Male:18, famale: 12, aged from 42 to 70, the average age 51.6±7.2 ; 30 age-matched health subjects as control group, male: 20, female: 10, aged from 43 to 69, Average 54.3±10.8. 2. Adopted elbow vein blood 4ml at days of 0, 3, 7, and 14. Serum samples were frozen in aliquots at -20℃within 1h of collection and avoided...