Expression Of Estrogen And Progesterone Receptors, VEGF And BFGF In The Endometrium Of Patients With Sympotomatic Uterine Leiomyomas

Objective: Uterine leiomyomas are the most frequent benign tumors in women and are responsible for menorrhagia and other forms of abnormal uterine bleeding.In clinic we found some patients with uterine leiomyomas had some symptoms that could not be explainded only by leiomyomas. For example, some patients with leiomyomas as large as pregnant uterus at 4-6 months of gestation had normal menstrual cycle or suffered from infrequent menstruation and scanty menstruation or did not suffer from menorrhagia until many years after the uterine leiomyomas had been diagnosed; some patients with little leiomyomas(1-2cm in diameter), even seed tumors, suffered from anaemia because of menorrhagia; some young patients with uterine leiomyomas who suffered from anaemia because of menorrhagia or severe menstrual dysfunction continued to complain menorrhagia after undergoing myomectomy. So we hypothesized there were changes in the endometrial microenvironment of some patients with uterine leiomyomas. The actions of estrogen(E) and progesterone(P) are mediated via the Estrogen and Progesterone receptors (ER and PR) localized in their target cells. The changes of levels of ER and...