Expression Of ADM And ET In Experimental Diabetic Nephropathy

Objective: With the increase of people's living standard and aging of population, the incidence of diabetes mellitus (DM) goes up year after year. Diabetic nephropathy (DN) is one of the common and serious diabetic complications. If albuminuria occurs, their illness cannot reverse and always result in end-stage renal failure at last. So it has great significance to research pathogenesis of DN for the effective prevention and keeping it from developing.Adrenomedullin (ADM), a 52-amino acid ringed-structure peptide, was originally isolated from human pheochromocytoma by a scholar of Japan, Kitamura, in 1993. It has great biologic effect, such as dilating blood vessel, reducing blood pressure, restraining cell s growth and proliferation, and so on. It is important for regulating renal function. Endothelin (ET), a 52-amino acid peptide, has the function of consumingly shrinking blood vessel and accelerating cell's growth and proliferation. ET-l can accelerate DN. It has been clearly proved that high-perfusion and hyperfiltration of glomerulus were the beginning factors of development of DN. ADM and ET-l are important vasoactive substance. But there were few reports about...