Effect Of Left Ventricular Doppler Diastolic Filling Pattern On Left Ventricular Asynchronization In Patients With Dilated Cardiomyopathy

Objective: To assess the effect of left ventricular Doppler diastolic filling pattern on left ventricular asynchronization in patients with dilated cardiomyopathy by analyzing transmitral and transaortic Doppler flow velocities with pulsed-wave and continuous-wave Doppler echocardiography and the time dispersity of electromechanical motion of four adjacent segments in left atrioventricular annulus with Tissue Doppler Imaging (TDI).Methods: 42 patients with dilated cardiomyopathy (including 18 patients with idiopathic dilated cardiomyopathy and 24 patients with ischemic cardiomyopathy, sinus rhythm, QRS≥ 120ms) were divided into two groups: 22 patients with restrictive LV filling pattern (age 59.2 ±14.7 years) and 20 patients with late LV filling pattern (age 56.6±12.8 years). The two groups were compared with 16 healthy controls of similar age (age 52.2±10.8 years). Resting transthoracic echocardiography was performed using a HP Sonos 5500 echocardiograph with a multifrequency transducer. Left ventricle end-diastolic dimension (LVEDD) and Left ventricle end-systole dimension (LVESD) were measured from the LV long axis M-mode guided by two-dimension view. Left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic volume (LVESV), stroke volume (SV) and left ventricular ejection fraction (LVEF) were acquired from the apical four-chamber view. Transmitral and transaortic Doppler flow velocities were recorded from the apical four-chamber and five-chamber views and then the peak velocity of early diastolic (Ev) , the atrial systolic transmitral flow (Av), Ev deceleration time (EDT), Ev/Av,...