Protective Effect Of Aspirin Against Dexamethason-induced Cataract In Cultured Rat Lens

Glucocorticoids play important regulatory roles in many physiological processes and have been widely and effectively used in medical practice. Steroid-induced cataract and glaucoma are typical problems in clinical ophthalmology. Epidemiological studies have documented that prolonged use of glucocorticoids with systemic, inhaled or topical steroid therapy can lead to the formation of a steroid-induced cataract. It is characterized as a posterior subcapsular cataract (PSC), which appears bilaterally and is distinguishable from the common types of cataract.Aspirin is unique among conventional non-steroid anti-inflammatory drugs, as it has both anti-inflammatory and cardio-protective properties. Numerous epidemiological and laboratory studies have demonstrated that aspirin can protect against the development of cataract. It has been reported earlier that aspirin may limit steroid-induced lens opacity in human. But there was no evidence of the effectiveness of aspirin as an anticataract agent against steroid-induced cataract in vitro.