Reversion Of Multidrug Resistance In A Gastric Cancer Cell Line SGC7901/VCR By Curcumin In Vitro

When tumor cells are resistant to one antineoplastic, they could be resistant to other antineoplastics with different structures and targets, this phenomenon is called as multidrug resisitance (MDR). MDR is an obstacle in gastric cancer therapy, owing to decreasing the therapeutic effect of chemotherapeutics. Scientists had researched largely to find the effective drugs which can reverse MDR. Chemical sensitizers including Verapamil and CsA can reverse MDR, however, they are restricted in clinic application because of the toxic and side effects. Recently, researchers are researching high effect, low toxicity and multitarget tumor MDR reverse agents. And many researchers pay attention to natural drugs. Traditional Chinese medicine has plentiful resource and multitarget, and it can aim directly to the complicated mechanisms of MDR. Present studies indicate developing the Chinese medicine reversing agents on tumor MDR will have a bright future.Aims: To observe if the plant extract curcumin can reverse the MDR in a drug resistant gastric cancer cell line SGC7901/VCR at low dose (no toxicity to cells); and if so, whether the expression and function of MDR protein P-gp are involved or not.Methods: (1) MTT assay, plate colony formation test and cell cycle analysis were used to confirm the MDR of SGC7901/VCR compared with...