To Study The Effect Of Atorvastatin On The Proliferation, Apoptosis And Cell Function Of Endothelial Progenitor Cells Induced By Oxidized Low-density Lipoprotein

BackgroundBone marrow of adults contains a subtype of progenitor cells that have the capacity to differentiate into mature endothelial cells and have therefore been termed endothelial progenitor cells (EPCs).Some investigation showed that the vascularization of adult tissue didn't simply occur via angiogenesis, the sprouting of new vessels from existing ones. It was concerned with bone marrow-derived endothelial progenitor cells (EPCs). Circulating EPCs come from bone marrow. They can migrate to sites of damage and participate in the neovascularization and repair of vascular endothelium. Chronic myocardial ischemia is mostly caused by atherosclerosis. And there's some lipidoses at local site. The increasing of hibernating or stunning myocardium or apoptotic cardiomyocyte caused by long-term myocardial ischemia leads to the progressing decrease of cardiac function in these patients. The number of blood capillary in ischemic region will be increased by the migration of EPCs to there and then growing into new vessel. Thus, the cardiac function will be improved. Recent...