The Construction, Expression, Purification And Bioassay Of Dickkopf1 Protein In E.coli

Melanin is the primary pigment producing brown coloration of the skin. Melanin is formed from tyrosine, via the action of tyrosinase, in the melanosomes of melanocytes. The melanosomes are transferred from a melanocyte to a group of keratinocytes called the epidermal melanin unit. Melanocytic hyperplasia and synthesis of melanin accentuation make hyperpigmentation. Hyperpigmentation is common in skin diseases, in which freckles, melasma and postinflammatory melanosis are most common. Hyperpigmentation that markedly take place on the face and the back of hand affects patient's feature and degrades patient's quality of life. According to the pathogenesy of hyperpigmentation, the measures that are adopted to prevent and cure hyperpigmentation include inhibiting melanocyte proliferate and activity, preventing melanin form and accelerating melanin degradation. But dermatologists are puzzled with the therapeutic effect, recurrence and adverse effect of all present therapies.Recent studies discover that the density of melanocytes in skin on the palms and soles is five times lower than that found in other sites of the body in adult humans, and that the melanin distribution and the expression of melanosomal proteins are also accordingly low. The reason is that the...