ADAR1 Expression In Acute Rejection Of Liver Transplant Rats And Detection Of ADAR1 MRNA Expressions In Hepatocellular Carcinoma Tissues

RNA editing is a process to re-modify the mRNA coding the genes, the enzyme which has the modifying function is called RNA editing enzyme. After transcribing DNA into RNA, the RNA editing enzyme changes the gene order and the genetic information by deleting, adding, or editing the nucleotide in pre-RNA, regulating the receptor-mediated signal transduction and then produces extensive physiological effect. RNA editase transform or modify the nucleotide of the pre-RNA by deaminization, and hydrolytic deaminize C6 amino group of the adenosine at the specific RNA site, changing adenosine to inosine or changing cytosine to uracil,but inosine was recognized as guanine in mRNA. These substitutions transform the original heredity codon or shearing site, and change the structure and function of the protein they coded.