The Effect Of QDTMT On Learning And Memory Ability In Rats With Bilateral Hippocampal Infarction

Background and aimIschemic cerebrovascular disease (ICVD), as a common disease of people, has done harm to human's health.Patients with ICVD often have some functional impairments. The impairment of the ability of learning and memory is common. Hippocampus is the vital structure of closely related to learning and memory of CNS,and it is vulnerable to cerebral ischemia.The pathogenesis is mainly related to apoptosis, calcium overload, oxgyen free radicals,reaction of astrocyte. Heat shock protein (HSP) often can be seen in the study of cerebral ischemia. HSP70 inhibits apoptosis of nerve cells and has the repairment ability against cerebral ischemia.It is said HSP70 can protect nerve cell against cerebral ischemia.Some researchers show that drugs can affect the expression of HSP70. The traditional Chinese medicine of reinforcing Qi and promoting blood circulation can improve the ability of learning and memory after cerebral ischemia. QDTMT is one of reinforcing Qi and promoting blood circulation traditional Chinese medicines. The past investigation shows that QDTMT can...