| Background Both clinical and experimental observations suggest that a number of autoimmune diseases occur more frequently in females than in males, such as a female-to-male incidence ratio of rheumatoid arthritis, systemic lupus erythematosus and autoimmune thyroiditis was 1:3, 1:9, 1:19 respectively. And it has been reported that the elevated plasma estrogen level during pregnancy can change the body immune conditions significantly, among which the shift of Th1 cell response to Th2 cell response suppresses Th1 cell-mediated autoimmune diseases such as MS, RA and EAE while worsens Th2 cell-mediated ones such as AITD and MG. Recently man pay more attention to effect of estrogen on the progression and pathogeneisis of autoimmune diseases, and it will provide a new way for the treatment of autoimmune diseases to explore its immunomodulation action and mechanism. Subramanian S. et al found the effective treatment of joint inflammation with orally administered ethinyl estradiol. And Offner H reported neuroimmunoprotective effects of estrogen and derivatives in experimental autoimmune encephalomyelitis. Colitis is also an autoimmune diseases, its... |
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