Effect Of Esmolol On Stress Response And Renal Function Following Laparascopy Surgery

Backgroud and AimWith laparoscopy becoming popular, surgery has gone into a new time. Short LC produce faint stress response, but long time laparoscopy produced different stress response in different literature. Few study is about how to reduce stress response . Esmolol is an ultra-short acting, cardioselective, beta-adrenergic blocking agent, which suppress β₁ receptor through competitively combined to the receptor against catecholamine in heart. Its distribution and elimination T_1/2 are short .Esmolol is commonly used in suprvarentricular tachyarrhythmias, acute coronary artery syndrom, perioperative or intraoperative tachycardia, hypertention and myocardial is chemia, et al abroad presently. Esmolol is safer than other long-acting beta-adrenergic blockers in patients with bronchial spasm, bradycardia or conduction block, hypotention and heart failure. To the effect esmolol on stress response, people have no conclusion. This study was performed to investigate the effect of esmolol on stress response and renal function, and evaluate the feasibility of intraoperative application of esmolol so as to provide theoretical basis for helping patients undergoing laparascopy surgery pass perioperative period safely. Material and Method30 patients (male, ASA I^II,age 47⁷9,weight 49⁸1kg, height 159¹78cm) undergoing elective neoplasty surgery for obligue inguinal hernia was included in the study. All patients had no deficiency in cardic or renal function and normal blood glucose level. They were randomly divided into controlled group (group C) and...