Pharmacokinetics And Relative Bioavailability Of Metformin-glibenclamide Release Tablets

Metformin and glibenclamide all have the function of lowering the blood glucose level, but the pharmacology are different. glibenclamide depend on the activation pancreatic (islet) b-cells that can cause the release of insulin to lower the blood glucose level. metformin depend on inhibition of the intestinal glucose absorption and the hepatic gluconeogenesis, it can increase the glucose uptake in the muscle and fat cells. The clinic find the cooperation of metformin and glibenclamide can help to lower the blood glucose level, we consulted metformin-glibenclamide capsule produced by ZhongHua Medicine Limited Company and studied pharmacokinetics and relative bioavailability of metformin-glibenclamide sustained-release tablets among healthy Chinese persons. It is expected that it could provide reference for the use of medicine in clinic.Objective To study the pharmacokinetics academic foundation and clinical use of metformin-glibenclamide in Chinese healthy volunteers.Methods Metformin-glibenclamide standard reference formulation (2.5g) and the test formulation (500mg) were given to 18 healthy male volunteers in a randomized cross-over study. The interval was one week. None of the subjects had a history of significant medical illness or hypersensitivity to any drugs. None of them had taken any other drugs for at least 2 weeks before the study and did not take any other drugs during the study. Their normal health status were judged on the basis of a physical examination with screening blood chemistries, including a complete blood count and liver function...