| [Objective]: Cadmium damage in young childhood is paid more attention gradually. To examine the some cause of the early prevention and treatment of cadmium damage, the factors significantly affected the cadmium level in umbilical cord blood, their influence on the development of child, and some mechanism were studied.[Methods]: 69 women at 30 weeks of gestation from the prenatal health care clinic were selected. Venous blood and umbilical blood at delivery were obtained and the blood cadmium levels were checked respectively. The self-designed questionnaire was used to collect the information about herself, her socio-economic conditions, and her partner. Some factors which affected the cadmium levels of venous blood and of umbilical cord blood were analyzed with single factor regression analysis. The significant factors were analyzed with stepwise regression analysis, the cadmium level of umbilical cord blood as dependent variable, the 32 factors as independent variable. The cadmium level of umbilical cord blood less than 1.60 μ g/L was normal group, otherwise was high Cd group. The influence of cadmium on physical and mental development of infant was studied. To examine the effect of cadmium on the biochemical indexes in young childhood, 48 healthy children (25 boys and 23 girls) from the child health care clinic were selected. According to their blood cadmium levels, they were divided into 3 groups: normal group, injury group of low Cd, and injury group of high Cd. Blood cadmium levels were measured with atomic absorption spectromentry method. The content of MDA was determined with thiobarbitone method, SOD with xanthosine oxidase method and IL-1β with double antiboby Sandwich ELISA method. The effect of Cd on MDA, SOD and IL-1β was examined.[Results]: ①Cadmium levels in maternal venous blood were 2.38±0.86 μ g/L... |
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