Effects Of Genistein On The MAPK Signal Transduction Pathways To Human Breast Cancer MDA-MB-231 Cells

The epidemiologic studies indicate that the incidences of many cancers are obviously different in various nations which due to the different eating habits. Among the dietary factors, genistein is a global focus because of the effects of anti-cancers in vivo and in vitro. Genistein is the primary reconstituent of the isoflavones rich in soybeans, which has been found to inhibit the cell proliferations of many tumor cells. The mechanism may be related to cell cycle arrest, cell apoptosis induction and the accommodation of signal transduction pathways. But the concrete mechanism of genistein has not been very clear yet.MAPK (mitogen-activated protein kinase) signal transduction pathway has a complicated network structure, which can transmit the outside signals to cells to regulate cell survival, cell proliferation or cell death. The abnormity of MAPK signal transduction pathways is related to many tumors and hyperplastic diseases. At present, four pathways have been identified: ERK1/2(extracellular signal-regulated kinase), c-Jun N-terminal kinase, P38 mitogen-activated protein kinase and ERK5,...