The Effects Of In Vivo Process For Solid Oral Dosage Forms

The efficacy of a drug is not only related to its biological activities, but also effected by the process in vivo. It is efficacious for a drug when its concentration achieves certain level after across all kinds of biomembranes. For an ideal drug, good in vitro bioactivies are not enough, good in vivo properties are needed. So it is important to study the ADME properties of a drug. We study the pharmacokinetics and bioequivalence of didanosine and telmisartan domestic and imported products, estimate the factors on bioequivalence for two drugs, respectively. We also develop a LC-MS/MS method to determine the concentration of (R,R)-formoterol in human plasma, and research the chiral biotransformation of (R,R)-fonnoterol in rats by CSP-HPLC-MS/MS, it can be used to study the metabolism profile and biotransformation of (R,R)-formoterol.It is necessary to study the in vivo process of a drug in drug discovery and development. The process in vivo and bioavailability of solid oral dosage forms are influenced by many factors, such as the physicochemical properties of a drug, dissolution profile of drug products, pathological and physiological situation of body,...