Changes Of Plasma Thrombin-Activatable Fibrinolysis Inhibitor In The Senile With Unstable Angina Pectoris And The Influence Of Low-Molecular-Weight Heparin

Background: Unstable angina (UA) is a common and multi-onset disease, which has serious effects on the health of the aged. The major pathogenesis of UA is the instability of local coronary atherosclerotic plaque and arterial thrombogenesis secondary to the plaque disruption. It has become a hot spot of precaution and therapy in coronary heart disease (CHD) that identifying and recognizing molecular mechanism of the plaque instability, then taking effective measures on prevention and cure.The more and more close attentions are paid to association between the development of CHD and active variance in the system of thrombosis and fibrinolysis. Recently, thrombin-activatable fibrinolysis Inhibitor (TAFI) has attached more importance as a factor regulatory to activity of thrombosis and fibrinolysis in cardiovascular and cerebrovascular diseases. Clinical studies have indicated plasma TAFI levels were related to development of angina pectoris and refractory UA Therefore, TAFI is likely to play a partial role in the development of UA, and the regulation of TAFI levels is potential significant to improve UA patients' clinical...