～(11)C-Choline PET-CT Image On Diagnosis Prostate Cancer And The Contrast Study Of MRI, MRS, Pathologic Results

Objective: The study aimed to clarify the utility of "C-choline PET-CT for prostate cancer. PET-CT were performed for evaluating prostate diseases by comparison with magnetic resonance (MR) imaging combined with proton MR spectroscopy and pathologic results.Methods: A total of 34 consecutive patients were devided as follows:â‘ Prostate cancer group: 16 cases (4 cases with well-differentiated adenocarcinoma, 9 cases with moderately differentiated adenocarcinoma, 3 cases with poorly differentiated adenocarcinoma), age range 55-90 years, mean age 68.2 years, serum SPA level ranged 9.0-135ng/ml, mean level 105.3ng/ml. â‘¡Benign prostate disease group: 14 cases with benign prostatic hyperplasia (BPH) (including 5 cases with prostatitis), 1 cases with high grade prostatic intraepithelial neoplasia(HGPIN), age range 53-85 years, mean age 69.4 years, serum PSA level ranged 0.06-13.28 ng/ml, mean level 4.65ng/ml. â‘¢Detection of recurrent prostate cancer after definitive therapy: 3 cases with moderately differentiated adenocarcinoma, two of three with serum PSA level 0.06ng/ml, the other one with serum PSA level 125ng/ml. 31 preoperated patients were ferformed ¹¹C-choline PET-CT imaging, MRI and MRS being performd a week ago. The group of one and three performed with ^99mT_c ECT and ¹⁸F-FDG PET-CT imaging within three days as well. The images were reviewed visually and semiquantitatively by using maximum standardised uptake value(SUV_max) and the mean value of SUV(SUV_mean) at the site of prostate diseases. The results of ¹¹C-choline PET-CT, MRI and MRS were compared to pathologic results which were acquired by radical prostatectomy or biopsies specimens.Descriptive statistics included sensitivity, specificity, positive and negative predicitive value of PET-CT,...