The Influence Of BFGF On Blood Circulation Reestablishment And Skin Grafting Repair In Fault Fibroareolar Fascia Wound After Escharectomy For Full-thickness Burn In Minipigs

ObjectiveTo explore the role of exogenous bFGF on blood circulation reestablishment in fault fibroarelar fascia wound after escharectomy for full-thickness,Definite whether exogenous bFGF can improve the fault fibroarelar fascia wound blood circulation.After exploration deep burn granulation tissue's forming process. From organism, organization, cell and protein molecular level to dynamic observe the fault fibroarelar fascia wound, prehension its healing process and exogenous bFGF's function in this process.MethodThis topic including animal experimental study and clinical study two parts. The animal experimentation selects the adult series III minipig 2 heads,their skin and the fibroarelar fascia organizational structure is similar with the human body,each pig designs 16 BSAs.32BSAs were randomly invided into A, B and C groups.Group A including 12 BSAs was sustained with full-thickness burn,at 7 PBD,the burn wounds were resected to the fibroarelar fascia level in which autos fault skin was grafted, exogenous bFGF was consperged into the wound before grafting. Group B including 12 BSAs was sustained with full-thickness burn,at 7 PBD, the burn wounds were resected to the fibroarelar fascia level in which autos fault skin was grafted. group C was the control group. At different time takes the...