Comparison Of The Neuromuscular Blockade Of Rocuronium After Prolonged Infusion During Isoflurane And Propofol Anesthesia

Objective To compare the neuromuscular blockade of rocuronium after prolonged infusion during isoflurane and propofol anesthesia.Methods Thirty ASA I or II,18-65 years old adults undergoing elective oral-maxillofacial carcinoma surgery, surgical procedures of relatively long duration(5h), were allocated randomly to either propofol anesthesia (group I, n=15) or isoflurane anesthesia (group II, n=15) . Neuromuscular block was monitored using train-of-four stimulation by a muscle relaxation monitor(TOF Watch SX). Rocuronium was administered in an initial bolus dose of 0.6mg.kg-1 followed by an infusion adjusted mannally to maintain the T1 ,the first response in the train-of-four,at 10% of control. Following cessation of rocuronium infusion all the patients were allowed to recover spontaneously. The follow variables were recorded:the infusion rate,spontaneous recovery index(T25-75) and the time interval from T1 at 10% of control to recovery of the TOF ratio to 0.9.Results At the fifth hour , the infusion rates were 8.18±0.62 and 5.49±0.68μg.kg-1.min-1 for the groups receiving propofol and isoflurane anesthesia. The latter was reduced by 30% compared to the former. For the two groups,spontaneous recovery index were 23.6±3.9 and 26.0±4.2min which were no significant difference.Conclusion Rocuronium can be administered as a continuous infusion for...