Dose-response And Gender Differences For Neostigmine Antag-onism Of Rocuronium-induced Neuromuscular Blockade

OBJECTIVE To evaluate the dosage of antagonization to neuromuscular blockade (T₁5% -10%) of rocuronium with neostigmine in adults.METHODS We study 45 adults aged 20-59 years and body mass index(BMI) 18.5-25 kg-m^-2, ASA I or II. All patients were undergoing low-risk elective surgery under general anaesthesia. This study were approved by the hospital Ethics Commtttee and all adult patients gave written informed consent. We exclude any patient suffering from cardiac, vascular, respiratory, hepatic, renal, neuromuscular disorder or small joint arthritis. Patients receiving medication known or suspected to affect normal neuromuscular transmission were also excluded. Patients who were randomly assigned to three groups received various dose neostigmine (N50 group received neostigmine 0.05 mg-kg^-1 and atropine 0.025 mg·kg^-1 ;N₄₀ group neostigmine 0.04 mg·kg^-1, atropine 0.020 mg·kg^-1 ;N₃₀ neostigmine 0.03 mgkg^-1 ,atropine 0.015 mgkg^-1at the end of surgery respectely. n=15 ).