Study On Beam Parameters Optimization With Genetic Algorithms In Intensity Modulated Radiotherapy

Radiotherapy, surgery and chemotherapy are the three main techniques for tumor treatment. It is estimated that, about 60%-70% patients suffering from cancer need radiotherapy. The development of three-dimensional conformal radiotherapy (3D-CRT),in which the high-dose volume matches the targets volume and avoids normal tissues, has been a major theme for improving the physical basis of radiotherapy, but it conforms only two dimensionally to the target projection in the plane perpendicular to the beam orientation, Intensity-modulated radiotherapy (IMRT) is the most advanced form of 3D-CRT, it can produce highly three-dimensionally conformal dose distributions to the target, significantly improve the five-year survival rate and the tumor growth control rate(TCP) of radiotherapy.IMRT, as a new accurate radiotherapy technology, is so complicated that the advantages of it have not yet been fully utilized until recently. There are many difficult problems, including how to select models of dose calculation and how to select the optimization methods of inverse planning to produce highly accurate dose, need to be dealt with. With the development of IMRT and inverse planning, the automatic selection of suitable beam parameters in external beam radiotherapy has gained wide interests, and is being studied by more and more researchers. There are...