The Suppressive Effects Of RsA In GN Rats

To investigate the suppressive effects and the mechanism of RsA in GN rats. We established a model of Chronic Serum Sickness(CSS) glomerulonephritis and Adriamycin Nephropathy(AN) in rats. RsA was orally administrated to model rats. The dosage of RsA was adjusted to 50mg/kg(body weight) in the low-dose group, 100mg/kg in the medium-dose group and 200mg/kg in the high-dose group. RsA was orally administrated to normal rats for 15 days to study the effect of blood rheology. In addition, we observed the effect of RsA on changes of urine volume in water-loaded rats. The results suggest RsA can significantly decrease the level of proteinuria, Scr, BUN, total cholesterol and IL-1, PDGF, while serum total protein and albumin markedly increase in CSSGN rats. The ratio of CD4+/CD8+ is also improved by RsA. However, RsA had no significant effect on adriamycin-induced nephropathy in rats. Whole blood viscosity was markedly decreased in normal rats by RsA. And RsA could increase the urinary volume of water- loaded rats.All these results indicate that RsA have a promising therapeutic effect on CSSGN rats. RsA may produce its protective effect on kidney through improving the blood circulation, inhibition of inflammatory cytokines and glomerular cell proliferation, improving renal function and the attenuation of the inflammatory infiltration of kidney.