| Objective To investigate the influence of intravenous infusion Betaloc on postoperative myocardial ischemia in patients with cardiovascular Disease undergoing noncardiac surgery during anesthesia , especially on the first day after surgery. We also assessed the effect between Betaloc and Muscle Relaxant. Methods Fifty-five patients ,who had an intermediate risk or two more lowers risk for postoperative cardiovascular events according to "ACC/AHA Guideline for Postoperative Cardiovascular Evaluation for Noncardiac Surgery" , were classified into two groups at random: Control Group (Group â… ,n=27) and Management Group (Group â…¡, n=28). Group I did not receive Betaloc. Group â…¡ was injected Betaloc 20ug/kg intrevenously before operation. Then pumped Betaloc0.1-1.0ug/kg.min continously .The heart rate of Group â…¡ was decrease 15%, but did not below 60 per minute , and blood pressure should not be less than 90/50mmHg. Holter was used to monitor all of the patients' heart rate, blood pressure and ECG, during 24 hours before operation , operation and 24 hours postoperative. The index of Holter was recorded. We also recorded patients' spontaneously breathing recovery time after stopping the use of muscle relaxant and the time of extubations after stopping the use of anesthetic. Patient's glycasemia was detected before operation, postoperation and the next morning after operation. Postoperation was going on up the time of discharge and also pay more attention the incidence of cardiovascular events. Results1. There was no significant difference between postoperative and preoperative heart rates in Groupâ…¡ (P<0.05) , but significant in Group â… . Groupâ…¡ had a low incidence of postoperative arrhythmia than Group I did (P<0.05) . 2. During the first postoperative 24h, twenty patients in Group I and five patients in Group â…¡ developed myocardial ischemia. There was significant intergroup variation between the two groups(P<0. 05). 3. As for patients' spontaneously... |
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