The Significance Of Levels Of PPARγ, S CD40L And MMP-9 In The Lesion Of Coronary Artery

Objective: To investigate the roles of s CD40L, MMP-9 and PPAR γ in atherosclerosis and analyze the reciprocity of these three factors and the degree of coronary artery lesion by the relationship study among s CD40L, MMP-9, PPAR-γ and the severity of coronary lesions in coronary heart disease patients.Methods: Ninety-eight inpatients with coronary heart disease (CHD) who undergone coronary angiography were admitted, meanwhile, 30 cases of age matched individuals with angiographic negative findings were selected as a control group. The severity of coronary artery lesion was conformed by coronary angiography. Enzyme Linked Immunosorent Assay was used to measure the level of s CD40L, MMP-9 in blood serum, the expression of PPAR-γ mRNA in lymphocytes located in peripheral blood was detected using RT-PCR. To analyze the relationship among s CD40L, MMP-9, PPAR-γ and the degree of coronary artery lesion and the reciprocity of them. Results: 1. s CD40L, MMP-9 level was significantly higher in CHD patients than those in controls (19.0±6.6 vs 13.4 ± 3.8; 1.3±0.15 vs 1.11 ±0.08). Significant decreasing was observed in CHD patients in PPAR- γ mRNA (0.4±0.12 vs 0.62 ±0.13) .2. Among CHD patients, PPAR-γ mRNA was significantly lower in 3 branches lesion group than 2 branches lesion group , and that of 2 branches lesion group lower than 1 branches lesion group (p<0. 01) , meanwhile, PPAR-γ mRNA was lower in C, Btype groups than those in A type group (p<0. 05) , and...