Effect And Mechanisms Of Magnesium On High Fat And Sucrose Diet Induced Obese Rats

Obesity and obesity related diseases are increasing in prevalence. Obesity can only occur when the energy value of food eaten exceeds energy expended. Magnesium (Mg) is one of the necessary macroelement in the human body, and is involved in more than 300 different enzymatic reactions, makes effect on almost all energy metabolisms. People who have obesity or obesity related diseases may have increased Mg utilization or Mg deficiency. Significant insights into the etiology of human obesity have been gained from the study of animal models. The present experiment was planned to study the effect of Mg supplementation on high fat and sugar diet induced obese rats and its probable mechanism. 1 Development of obesity animal modelsMg was supplemented into the high fat and sucrose diet during the experiment. Metabolism and pathology changes were observed to study the effect of Mg supplementation on high fat and sucrose diet induced obese rats. The rats were divided into six groups: the normal diet group, the low Mg diet group, high fat and sucrose diet group and Mg supplementation groups (500mg/kgMgO, 1000mg/kgMgO, 2000mg/kgMgO). The animals were killed after 9 weeks, the body weight, VF/weight, organ coefficient, blood and muscle Mg content and other obesity parameters were measured. Abdominal fat tissue and skeletal muscle were collected to be made in paraffin-embeded specimens.The results showed that the weight and weight gain of high fat and sucrose diet group were higher significantly than the low Mg diet group (P<0.05). The VF/weight and liver coefficient of high fat and sucrose diet group was higher significantly than the low Mg diet group (P<0.05, P<0.01). The level of serum TC, TG, VLDL of high fat and sucrose diet group was higher significantly than the low...