MR Diffusion Weighted Imaging To Acute Carbon Monoxide Poisoning Of Rabbit Brain

Objective Apply MR diffusion weighted imaging to monitor the changes of the ADC value of rabbit brain in acute carbon monoxide poisoning, and compared with pathology , probe the diagnosis value of MR diffusion weighted imaging in acute carbon monoxide poisoning and attempt to find a marker which can predict the delayed encephalopathy of carbon monoxide poisoning. Methods 15 animal(rabbits) model of acute carbon monoxide poisoning have established by static absorption method, and 13 succeeded. MRI function technique( this article mainly talk about MR-DWI) is applyed to dynamicly observe the cerebral damage at the first hour, the 3^th, 5^th, and 7^th day after poisoning, and measure the ADC value of cerebral cortex., compare with prepoisoning ADC value respectively and combine with pathology. At the same time, . we have observed repeatedly clinical appearance of the poisoned rabbits for 60 days, and divided into 2 groups according to the different clinical apperances. One group occurred delayed encephalopathy and the other group did not. Results All the ADC value of cerebral cortex of poisoned rabbits descended after 1 hour, and the average ADC value had statistical significance (P<0. 05) compared with the ADC value of the prepoisoned. Otherwise, in unoccurred delayed encephalopathy group ,...