Detection Of Serum Soluble Intercellular Adhesion Molecule-1 And Its Implications In The Patients With Chronic Severe Of Hepatitis B.

Objective: To investigate the changes of serum soluble intercellular adhesion molecule-1 ( sICAM-1) and its clinical significance in the patients with chronic severe of hepatitis B.Methods : Serum soluble intellcellular adhesion molecule-1 in the 50 chronic severe hepatitis B patients and 30 normal persons were detected by double antibody sandwich ELISA. The serum level of HBVDNA and HBV markers in 50 patients are detected by FQ-PCR and ELISA respectively. Automatic biochemistry analyzer was used for measuring serum level of liver function in 50 chronic severe hepatitis B patients. Automated coagulation analyzer was used to measure the serum prothrombin activity in 50 chronic severe hepatitis B patients.Results:1.Serum levels of sICAM-1 in patients with chronic severe hepatitis B were significantly higher than that in normal persons. (P<0.01) Serum levels of sICAM-1 in the survivals group was obviously higher than that in the patients which ended with death. (P<0.01) 2.The serum sICAM-1 level in the patients had a positive correlation with prothrombin activity (r=0.475 P<0.01) , a negative correlation with bilirubin (r=-0.395 P<0.01) , no correlation with alanine aminotransferase (ALT) and albumin(ALB).( r= 0.014,-0.214, P>0.05) 3.There was no significant difference of the serum sICAM-1 level between the patients with the HBV DNA<10~5copies/ml(27 cases) and HBVDNA ≥10~5copies/ml(23 cases).