Experimental Study On Antitumor Effect Of Gallic Acid

At present,malignant tumor has become a major cause which influences people's quality of life and threatens people's health severely. So the urgent affairs are to study the pathogenesis of tumor and develop effective anti-tumor drugs which can help the sufferers racked with cancer improve their quality of life and prolong their life. With the development of study, researchers recognize that apoptosis is a cellular voluntary death controlled by gene and different from necrosis in morphological and biochemical characters. Killing tumor cells by inducing apoptosis can protect the normal tissues of organism from intensive inflammatory reaction. Therefore researchers pay more attention to the task of developing drugs which can induce apoptosis of tumor cells.Gallic acid is a kind of Phenols compoud that is abstracted from plants,and it has extensive biology effect, The present study was conducted to estimate the anti-cancer activity of GA in vitro and in vivo, and the mechanism of action.Purposes: To evaluate the antiproliferative activity of GA in vitro and in vivo and to elucidate potential mechanisms of action.Methods: The killing ability of GA on cancer cell was measured by MTT; Tumor growth inhibition activity of GA was measured by murine bearing in vivo; S180 cells were stained with HE after exposed with various concentrations of GA to do the morphology examination; Cell cycle was analyzed by flow cytometry; The expression of bcl-2 and bax were analyzed by immunohistochemistry.Results:...