Effect Of The Expression Of CAM On HUVECs Induced By DV₂

BACKGROUNDThe dengue virus can produce a mild, self-limited febril illness or a severe sickness, known as hemorrhagic dengue and Dengue Shock Syndrome, which may endanger the life of patients. The most characteristic features of DHF/DSS and the best indicator of disease are vascular leakage and hemorrhaging which has suggested that dysfunction of blood vessel play an important role in the development of DHF/DSS.Vascular endothelial cells play important roles in regulating vascular permeability and maintaining the normal blood dynamics. DV can infect VECs, but little was known about the CAMs expression induced by DV. Some pathogenic infection can activate VECs and the activated VECs may express and secrete some CAM excessively. The increased production and over-expression of these molecules may take part in the inflammatory cell effusion and enhanced locally inflammatory reactions. So we speculate in the molecular level that the activated and damaged vascular endothelial cells which are in dysfunction can induce the molecules in disorder, change internal environmental homeostasis and increase vascular permeability. These will play important roles in the process of blood leakage and hemorrhage.Clinical and in vitro related studies support the changes of VECs, but because of no ideal animal models, up to now, the studies remain in vitro, and we know little about the changes of CAM induced by DV though the process of plasma leakage and hemorrhage. So the study of the expression of AM on VECs infected by DV may play important roles in completely elucidating the pathogenesis of DHF/DSS.