Clinical Study Of Dynamic Of Pituitary Hormones And MRI Features In Patients With Acute Severe Craniocerebral Injury

Objectives: The purpose of this study was to investigate the clinical significance of the change of pituitary hormones and the MRI features of hypothalamus and pituitary in patients with acute severe craniocerebral injury.Methods: 30 patients who developed acute severe craniocerebral injury hospitalized in the First Affiliated Hospital of Jinan University between April 2005 and March 2006 were included in the study. Test their pituitary hormones of GH, PRL, ACTH, TSH, FSH, and LH at 7am on the 1^st day, the 3^rd day, the 7^th day, the 14^th day and the 30^th day respectively. The patients were divided into two groups according to the GCS scores: the severe group) and the very severe group ((GCS score 3-5). A control group was set up, and the data of the three groups were analyzed. The patients were randomly divided into two groups, one group accepted dexamethasone treatment, and the other group did not. Pituitary hormones levels of the two groups were compared. All the patients had MRI tests, analyzed the relationship between pituitary hormones levels and the MRI features.Results: The levels of pituitary hormones in acute severe craniocerebral injury patients were increased compared to those of the control group, except TSH and GH. The level of TSH was decreased, and GH had not marked difference compared to the control group. The trends of pituitary hormones levels in acute severe craniocerebral injury patients were increased immediately after injury, except TSH and GH. The trend of TSH level was decreased, and GH remained unchanged. And then the hormones levels were gradually decreased or increased, most of which came to a...