Clinical Analysis With Ulcerative Colitis P-ANCAs: Experience Of 30 Cases

Background and Objective: Ulcerative colitis (UC) is a chronic disease of unknown etiology characterized by inflammation of the mucosa and submucosa of the large intestine. UC is the main clinical entity of inflammatory bowel disease (IBD). The diagnosis of UC is usually straightforward, based on a detailed history and physical examination, along with radiographic investigations and standard endoscopic, biopsies. These examination not only consume time, but also bring the great pain to the patients. More challenging is the search for clinically useful, noninvasive markers for ulcerative colitis to diagnose, especially to accurately screen cases with nonspecific and indolent symptoms. In recent years, serologic marker has been found to be useful for the diagnosis and differentiation of UC. This marker is atypical perinuclear anti-neutrophil cytoplasmic antibodies (P-ANCAs), have a high sensitivity, specificity and positive predictive value in diagnosing UC. For that 30 inpatients with UC were selected to determine the clinical impact of P-ANCAs testing by evaluating how this test was used in the disease.Methods: The patients studied were 30 patients with UC of the first affiliated hospital of Dalian Medical University from 2006.1.5 to 2006.12.21. According to the definition of gender, length of disease(<5 year, 5～10 year, >10 year), activity of disease (as scored by Truelove and Witts criteria, mild, moderate, severe),extent of the disease(proctitis, proctosigmoiditis, left side colitis, extensive colitis), patients were classified into the following clinical subgroups. Examine the difference of P-ANCAs prevalence and analyze the result by statistics.Results: According to P-ANCAs status, Percentages of P-ANCAspositivity was 46.7% in patients with UC. The presence of P-ANCAs was strongly correlated with UC gender and activity of disease (P < 0. 05), prevalence rates were no different as far as length of disease, and extent of the disease were concerned (P > 0. 05).Conclusions: In our study, P-ANCAs is the serologic marker for UC. The presence of P-ANCAs is correlated with UC gender, It shows that the prevalence rate in female with UC is higher than in male with UC. The presence of P-ANCAs is strongly correlated with UC activity of disease. No significant difference of P-ANCAs prevalence is found between length of disease and extent of the disease.but P-ANCAs prevalence is ascending as the expending of extent of the disease. P-ANCAs is useful in helping disease diagnosis. So the diagnosis of UC is based on a detailed history and physical examination, along with radiographic investigations and standard endoscopic, biopsies. It may be the secondary diagnosis and significant to explain the mechanism to UC.