A Control Study Between Isoflurane And Sevoflurane Anesthesias In Abdomen Surgery With The Closed-Loop Anesthesia System

Objective: forty adult patients scheduled to undergo elective abdomen surgery were enrolled into either of the two groups: isoflurane group and sevoflurane group. The maintenance of patients' anesthesia was controlled by the closed-loop target-controlled infusion system with isoflurane in the isoflurane group and sevoflurane either. A control study was performed between isoflurane and sevoflurane to assess their stability of BIS, the stability of hemodynamics, the doses of ether used, the quality of induction and emergence in the anesthesia with the closed-loop anesthesia systemMethods: forty adult patients scheduled to undergo elective abdomen surgery were enrolled randomly into either of the two group: isoflurane group and sevoflurane group. All the patients were injected propofol (1.5-2mg·kg^-1 ) intravenously till the eyelid reflex was disappeared ,then Fentanyl(0.4μg·kg^-1) and pipecuronium(0.08-0.1 mg·kg^-1 ) were injected intravenously to facilitate endotracheal intubation.. The process of maintenance was controlled by the closed-loop target-controlled infusion system with isoflurane in the isoflurane group and sevoflurane either. An intra-operative target bispectral index of 55 was set in all cases. Adequacy of anesthesia and change of hemodynamics during closed-loop control were assessed clinically and by calculating BIS. The stability of hemodynamics, the quality ofinduction , the doses of ether usedand emergence were also studied in two groups. Results: no statistical difference was observed in BIS, HR and pulsepressure(PP) in two groups. oscillations of BIS and SBP in sevoflurane group were statistically less than these in isoflurane group during the maintain of operations, but there were no difference in DBP and HR. EO time was statistically less in sevoflurane group. Times of restlessness showed no difference in two groups. The sevoflurane group used less ether but the doses of ephedrine and Ebrantil used in anesthesia were not statistically different. no patients reported awareness or recall of intraoperative events.Conclusions: Both isoflurane and sevoflurane anesthesia with the closed-loop anesthesia system are qualified for abdomen operations. And sevoflurane group patients showed statistically less oscillations of BIS and SBP during the maintain of operations and less restlessness and use less ether.