Preemptive Analgesia Effects Of Flurbiprofen Axetil On Respiratory Function In Patients Undergoing Thoracotomy

There is considerable pain after thoracotomy and can cause regional impairment of ventilation, ineffective cough, and impaired ability to sigh and to breathe deeply . These changes can suppress the respiratory function also increase respiratory complications postoperatively. Evidence has accumulated since the early 1980s confirming that these changes can be minimised and even prevented by effective analgesic techniques, especially if analgesia is started preemptively and continued postoperatively until would healing has taken place. The traditional pain relief method of giving analgesic when the patients request can't inhibit central sensitization successfully. Now we introduce the concept of preemptive analgesia which means an antinociceptive treatment that prevents establishment of altered processing of afferent input.Flurbiprofen axetil is one kind of NSAIDs which can block the nociceptive response to endogenous mediators of inflammation by reducing PGs synthesis. We combined preemptive analgesia with PCA to cover both the period of surgery and the initial postoperative period which can maximumly inhibit central sensitization. We take respiratory function as clinical index to measure the effects of preemptive analgesia.To access whether effects of flurbiprofen axetil preemptive analgesia have clinical significance or not.Objective: To access the preemptive analgesia effects offlurbiprofen axetil on respiratory function in patients undergoing with thoracotomy.Methods: Twenty male patients underwent thoracotomy thoracic surgery were randomly allocate to two groups equally with ten cases each to receive either flurbiprofen axetil 5ml (50mg) or Sodium Chloride 5ml 15min before incision . At the end of the surgery both groups received intravenous Sufentanyl PCA with a loading dose of 10μg, a maintenance dose of 2μg/h, a bolus dose of 2μg and a lockout interval of 15 min. Age, weight, sex, history of general anaesthesia were recorded. Analgesia grade at 4h,8h,12h,24h,and 48h after operation were accessed also side effects(nausea and vomiting) were recorded. Total drug use, number of boluses delivered, number of boluses demanded were collected. Pulmonary function was tested the day before operation , as well as at 24 and 48h after operation.Results: No differences among groups were found for demographic data. There were also no clinically relevant differences between the groups with regard to side effects(p>0.05). Significant differences were observed in analgesia grade between two groups. Visual analogue scores was lower in group F than that in group C(p<0.05). Also less bolus doses were demanded and delivered in group F(p<0.05). Respiratory function test was better in group F than that in group C but there was no significant difference.Conclusion: Flurbiprofen axeti1 has preemptive analgesia effects with the chosen dosage regimen in patients undergoing thoracotomyand don't increase side effects. But the preemptive analgesia can't improve postoperative respiratory function.