An Analysis About The Antibiotic Resistance Of Bacteria In Respiratory Department Of Our Hospital During The Period Of 2005-2006

Since the anti-infection drugs were applied in clinic, the mankind have already obtained magnitude effect with various infection which are caused by pathogenic animalcules. In succeeding research, people discovered bacterial drug-resistance, resistance mechanism and the main reason causing resistance-the antibacterial's unreasonable application. Antibacterial's abroad usage brings on a series of side-effect, except antibacterial's abuse would damage body organs, the more austere result is that antibacterial's abuse would destroy body's natural bacteria clusters, which will enhance the pathogen drug-resistance leading to the disease incorrigible. Meanwhile antibacterial's abroad application brings on drug-resistance's rapid emergence, that makes cure difficult. In order to using antibiotics in reason, controlling disease as soon as possible, improving cure rate, the paper examines and analyses sufferers'phlegm cultivation and drug-allergic results, who had hospitalization in the respiratory department of our hospital during 2005-2006 years.The phlegm cultivation amount is 740, bred and separated 192 bacteria, the check rate is 25.9%. There were 17 Gram Positive Bacteria, which had a rate of 8.9% in all infection germina; and 77 Gram Negative bacteria, which had a rate of 40.1%, the main bacteria are Verdigris Pseudomonas, Klebsiella Pneumoniae and large intestine Escherichia; 98 epiphyte which had a rate of 51.0%, the main are Microzyme, Candida Albicans. Verdigris Pseudomona bacteria's number is 14 having a rate of 7.3%, Klebsiella Pneumoniae bacteria's number is 11 having a rate of 5.7%, Genus Enterococcus bacteria's number is 5 having a rate of 2.6%, Microzyme bacteria's number is 60 having a rate of 31.3%. Compare Gram Positive bacteria with Gram Negative bacteria, Gram Positive bacteria resistance ratio to Penicillium is 78.6%, Gram Negative Bacteria were resistant to majority of the second and third generational Cephalosporins, but the sensitivity to complex enzyme preparation was passable, and were sensitive to Quinolones and Aminoglycosides antibiotics. Gram Positive bacteria's drug-resistance to the fourth generational Cephalosporins antibiotics is high to the rate of 68.8%. Gram Positive bacteria and Gram Negative bacteria both had high drug-resistance to Imipenem drug such as Meropenem.The research shows that the check rate of clinical phlegm cultivation is low, there wasn't unqualified phlegm sample, but we still need to notice the phlegm samples quality. The basic requirement of the phlegm bacteria cultivation samples is gargling, morning phlegm, coughing deeply and checking in 1h. In other side low separating rate was due to experimentation condition limitation, and due to the samples were gained after using by antibacterial. So I think lab separating methods should be improving and we should strengthen the animalcule lab's building. The epiphyte check rate was higher than 50%, should avoid allergic disease that caused by inbreathing epiphyte antigen. In addition , applying antibiotics should be reasonable to avoid second infection or multi-infection and coming forth serious epiphyte drug-resistance. Familiar causing pathogen such as Verdigris Pseudomonas bacteria,Klebsiella Pneumonia bacteria, Enterococcus bacteria, should be noticed their drug-resistance mechanism. We should select allergic antibiotics according to the drug-allergic experiments results, control the diseases as soon as possible, heighten cure rate, lighten patient's suffering, notice to adjust patient's body immunity state.Applying antibiotics reasonably is for using antibiotics safely and effectively, namely assuring effect in the precondition of safe, that's the basic principle to use antibiotics reasonably. Using antibiotics reasonably need to analyse concretely according to patients'concrete condition, design individual cure programme. And there isn't the same programme can be used in different conditions. Selecting antibiotics having good pertinence is the key to obtain anti-infection treatment. Because of lab and region difference, when there isn't pathogeny germ drug-allergic result, to cure major light and medium infection diseases and the first treatment of heavy disease infection, experiential treatment are still the main method in anti-bacteria cure, so still need to apply objective treatment positively. Experiential using drug programme shouldn't be designed only according to doctor's individual will. Successive experiential drug using is commonly constructed on epidemiology investigation about the same type infection pathogeny series, drug-resistance monitoring, randomly comparison on clinical experiment and former objective treatment base. It should decrease drug-resistant germ's appearance, lighten the pressure on the germs.Drug-resistant monitoring can make up the defects due to the bacteria report can't be obtained timely. Sum up the main disease pathogen's drug-resistance rules of the regional and hospital on base of magnitude and long-term drug-resistance monitoring data. Design reasonable treatment programme, which has important meaning in decreasing bacteria drug-resistance rate, controlling hospital infection effectively.