The Study On Pharmacodynamics And Active Mechanism Of Active Part Extracted From Cordyceps Militaris

Objective In order to provide scientific basis for the development and application of cordycep militaris, we furthered the research of mechanisms of its sedative and hypnotic effect and reduction of blood fat through studying the main pharmacodynamics of its active parts.Methods â‘ The experiments of normal hypoxia tolerance and acute cerebral ischemia and anoxia tolerance were performed. Promotion of immunologic function was observed through the testes of serum hemolysin, antibody-forming cell and clearance of carbon with the low immunity mice model caused by Cytoxan. Experiments of autonomic activities of normal mice, extend time of sleep caused by pentobarbital and hypnotic test of subdissociative dose of pentobarbital were carried out to observe the effect of sleeping function; the content of TG, TC, HDL-C of mice and rat were determined.â‘¡The content of monoamine neurotransmitter such as 5-HT, 5-HIAA, DA, NE etc were determined by RP-HPLC ,and the content of SOD and MDA of hyperlipidemic mice were determined by UV-VIS. According to the change of those indexes, the mechanism of anti-insomnia and reducing blood lipids of active part extracted from cordycep militaris were discussed.Result â‘ The active part of cordyceps militaris can enhance the tolerance of mice to anoxia under normal pressure and the tolerance of mice to acute cerebral ischemia and anoxia, improve phagocytosis function of serum hemolysin, antibody-forming cell and mononuclear macrophage cell of immunosuppressed mice, reduce autonomic activities of normal mice, prolong time of sleep caused by pentobarbital and hypnotic test of subdissociative dose of pentobarbital, and reduce content of TG of...