Insulin Resistance, Body Composition And Body Fat Distribution In Women With Polycystic Ovary Syndrome.

Objective: The polycystic ovary syndrome (PCOS) is a kind of common gynecologic endocrinology disorder. Approximately 50% of patients with PCOS are overweight or obese. It is characterized by hormonal and metabolic imbalance. So far hyperandrogenaemia, insulin resistance and hyperinsulinemia are major features of this metabolic disease. The hyperinsulinaemia present in PCOS women appears to be independent of obesity. The fat distribution patterns has gradually gained attention from epidemiological studies due to its independence as risk factors in sorts of disturbances, abdominal obesity is associated with metabolic syndrome, increases the risk of breast cancer and endometrial cancer, and accordingly, the aim of this study was to evaluate the effect, if any, of obesity and lean on metabolic features, body composition and fat distribution in patients with PCOS so as to provide therapeutic recommendationsMethods: 31 infertile women with PCOS (14 in obese group and 17 in the non-obese) and 64 controls in reproductive age were recruited with matched age. Peripheral blood were sampled for endocrinological and biochemical measurements during 2-5 days after initiating menstruation or any time when predominant follicle was not identified by B-mode ultrasound. At same day of sampling, height, weight and waist circumference were measured and body mass index (BMI) was calculated. BMI ≥25kg/m~2 were defined as obesity. Body composition were determined by DXA, and body bone mineral density (BMD), bone mass, muscle mass, fat content,...