A Clinical Research Of Using Glutamine Effects On Intestinal Permeability And Bacterial Translocation In Abdominal Postoperative Patients

AIM: To observe the effects of operation on abdominal region on the plasma glutamine concentration, the intestinal mucosa permeability, the percentage of bacterial DNA present in blood of surgical and SIRS score. By comparing above indexes, prove the possibility of bacterial translocation from intestine after operative on abdominal region. And using glutamine could prevent intestinal barrier function and decrease the happening of SIRS.METHODS: 34 patients with undergoing major/median surgery on abdominal region were randomized divided into two groups: Control group (n=17) and Treatment group (n=17). All patients were supported by PN from the 2ed day of postoperative. Patients in Treatment group received glutamine-enriched parenteral nutrition(dipeptive 0. 5g · kg^-1·d^-1) from 2ed day of postoperative. Accordingly, Control group received ordinary PN. The plasma glutamine concentration, the urinary lactulose/mannitol (L/M) ratio, the percentage of bacterial DNA presenting in peripheral blood, SIRS score (the day before operative, 2ed day and 7th day of postoperative) and the type of operation were detected. The relationships of them were analyzed by the statistical methods. RESULTS:1. In the 2ed day of postoperative, the concentration of plasma glutamine was significantly lower than the preoperative in both...