Study On Preparation And Properties Of Amphiphilic Multi-copolymerized Scaffolds

In this paper, in order to improve hydrophilicity of poly lactic acid(PLA), and adjust its mechanical property and degradability, then improve its biocompatibility, the double bond end-functionalized PLA macromonomers and biodegradable crosslinking agent was firstly synthesized, and then the graft copolymers, cross-linked copolymers and cross-linked terpolymers were prepared by multi-copolymerization. Then their physical and chemical properties were characterized, and their biocompatibilities were studied.1. PLA macromonomers and biodegradable crosslinking agent was synthesized. The results of FT-IR, ~1H NMR and GPC showed that the chemical structure and molecular weight of the polymers was consistent with the expectation.2. The amphiphilic graft copolymers were synthesized by copolymerization of the poly(D,L-lactide) macromonomer and N-vinyl pyrrolidone(NVP). The results of FT-IR, ~1H NMR and GPC showed that structure of the copolymers was consistent to the expectation. The results of the investigation on the hydrophilicity, biocompatibility and degradability indicated that compared to pure PLA, all the copolymers had higher hydrophilicity, good blood/tissue compatibility and non-cytotoxicity, their degradability could be regulated by feed molar ratios.3. A series of cross-linked copolymers were prepared by copolymerization of biodegradable crosslinking agent and PLA macromonomer initiated by ultraviolet(UV). The reaction process was studied by curing time test and gel content test. The results of FT-IR analysis, contact angle test, swelling ratio test and mechanical property test showed that chemical structure and properties of the cross-linked copolymer were changed with different feed molar ratios.4. Based on the research above, a series of cross-linked terpolymers were prepared by terpolymerization of macromonomer, biodegradable crosslinking agent and NVP initiated by UV. The results of characterizing on chemical structure and properties of the cross-linked terpolymer indicated that its cross-linking density could be adjusted by feed ratios, then its...