The Study Of Oxcarbazepine By Transcranial Magnetic In Patients With Epilepsy

Objective To evaluate the effect of monotherapy (Oxcarbazepine ,OXC) on the motor threshold(MT), cortical latency (CL), peripheral latency(PL), central motor conduction time(CMCT) and motor evoked potential amplitude(MEP amplitude), using transcranial magnetic stimulation(TMS) in patients with epilepsy.Methods A single pulse transcranial magnetic stimulation was used for recording the motor-evoked potentials(MEP) from the thenar muscles of both hands, in 42 patients with epilepsy, who were with normal brain MRI and treated with OXC or CBZ. The MT, CL ,PL,CMCT and MEP amplitude were recorded and compared with 20 healthy controls. The recording sessions were performed before treatment and after 14, 28days . Results In patients before treatment, the MT was significantly (P<0.05) low compared with the healthy controls, but it increased significantly(P<0.05) after OXC or CBZ. And no significant differences were observed on MT between patients with OXC and CBZ. Also, no significant changes were found on CL ,PL,CMCT and MEP amplitude among controls, patients before and after treatment. Conclusion Single pulse TMS is able to provide a valuable electrophysiologic insight into the interical excitatory state of cortex in patients with epilepsy. Both OXC and CBZ reduced the membrane excitability of human motor cortical neurons, possibly through changes in Na~+ channel activity.