The Clinical Study On The Treatment Of Jinlingbushen Powder To Chronic Pelvic Inflammatory Disease

Background: Pelvic Inflammation is a common and frequently occurring disease in women of childbearing age. Generally, about 3% females had this trouble during all their lifetime. It can cause sequelae such as ectopic gestation, sterility, chronic pelvic pain, salpingian dropsy, tuboovarian cyst and chronic dyspareunia, which affect the female health greatly and increase the domestic and socioeconomic burden. Therefore, diagnosis and treatment of chronic pelvic Inflammation has been emphasized in clinical gynecology. Based on "strengthening healthy qi to eliminate pathogens", the traditional Chinese medicine (TCM) exhibited superiority over this and took better effect through multiple medications.Objective: To observe the curative effect of Jinlingbushen Powder on chronic pelvic inflammatory disease.Methods: All 90 cases came from the gynecology outpatients (First Affiliated Hospital, Guangzhou University of Traditional Chinese medicine) and Hong Kong XinMing clinic. They were divided into treatment group including 60 patients and control group involving 30 patients. The final diagnosis was in accordance with Guidelines to clinical research in new drugs of TCM. The treatment group were given Jinlingbushen Powder, consisting of nutgrass galingale rhizome, corydalis tuber, Curcuma aromatica, toosendan fruit, danshen root, prepared pinelliae tuber, Poria cocos Wolf, FRUCTUS AMOMI, cibotium barometz, cuscuta seed, zingiberis recens, Nanzao. Chang of medication: herba leonuri was added during menstruation; when obvious humid heat characterized by pyrexia, deficient cold foul leucorrhea, dry mouth, yellow urine, coprostasis, red texture of tongue and yellow or yellowish greasy tongue occurred, hedyotic diffusa and dandelion were supplemented; cumin was given for cold coagulation; abdominal lump was treated with common burreed tuber and zedoary rhizome. To be decocted in water for oral dose twice a day. The control group were administrated Jingangteng syrup 20 ml twice a day. One month was defined as one course of treatment. Physician orders: work and rest, emotional regulation, good nutrition, no raw and cold food, no sex during onset.Results 1. Both groups were mainly 20-39 years old, which demonstrated chronic pelvic inflammatory disease occurred more frequently at chiid-bearing age in females with vigorous sexual activity.2. The course of disease was 7-24 months, which indicated long-term and lingering disease. Jinlingbushen Powder improved hypogastralgia, lumbosacral and menstrual abdominal pain obviously. The total effective rate clinically in the treatment group was significantly higher than in the control. Jinlingbushen Powder improved the abnormal leucorrhea and the total effective rate clinically in the treatment group was also significantly higher than in the control. After treatment, pelvic lump in the treatment group reduced (P＜0.05). Although the lump in the control also reduced, there was no statistical difference (P＞0.05). So Jinlingbushen Powder significantly reduced the pelvic lump. As for the hemorheological index, whole-blood high shearing viscosity and blood viscosity in the treatment group was lower than in the control (P＜0.05). But in contrast to clinical symptoms, the minicirculation in chronic pelvic inflammatory disease recovered slowly. Thus, after controlling the symptoms, further "promoting blood flow to remove blood stasis" therapy was needed to improve the hemorrheology as well as the area of pelvic lump.Conclusions: Jinlingbushen Powder, based on the theory of activating qi and promoting blood to remove stasis and tonify kidney-spleen, improved hypogastralgia, lumbosacral pain, abnormal leucorrhea, menstrual pain. Besides, it reduced the pelvic lump and improved hemorheological change. Although similar to Jingangtengin controlling some symptoms such as fluctuatingl low-grade fever, lassitude, irregular menstruation, the total effect of Jinlingbushen Powder was superior. The curative effect was obvious, steady and lasted long. Side effects haven't been found so far. It is worth further study and extension. For patients with recurrent attacks, long-term medication can be given in order to maintain the therapeutic effect. However, at the same time of drug treatment, good nutrition, work and rest, strengthening constitution are important to reinforce the immunity.