Comparative Analysis Of Clinicopathologic Factors And Metastasis Of Lymph Node Between Upper Stomach Adenocarcinoma And Lower Gastric Carcinoma

PrefaceGastric carcinoma is the more common malignancy in clinical. The morbidity is the highest in gastrointestinal tumor. The surgical treatment in gastric carcinoma have been reasonable,norms standard program, including tumor Biology and immunology,anatomy. As we all knowing, the gastric cancer prognosis not only depend reasonable, appropriate treatment, but also depend their pathology biology behavior and lymph node metastasis. This research wants to analysis pathology biology behavior and lymph node metastasis between upper stomach adenocarcinoma and lower gastric carcinoma, to find their different and impact on the prognosis. We can get something in this research to treatment gastric carcinoma.ObjectiveTo analysis the clinicopathological parameters of gastric cancer samples resected by surgery at the Department of Oncosurgery, First Affiliated Hospital of China Medical University, approach the variability of clinical pathobiology and corresponded regularity of lymph node metastasis between Upper Stomach Adenocarcinoma and Lower Gastric Carcinoma. Reveal the its clinical significance, in order to adopt reasonable,utility and standard therapeutic regimen for gastric cancer.MethodsCollect 1837 gastric cancer samples resected by gastric cancer standard radical MethodsCollect 1837 gastric cancer samples resected by gastric cancer standard radical correction (D2) or expansion radical correction (D2 above) at the Department of Oncosurgery, First Affiliated Hospital of China Medical University from September 1981 to September 2001, which were radical cured degree A or B. There were 1360male and 517 female patients , in which 321 cases are upper stomach adenocarcinoma,1516 cases are lower gastric carcinoma. All cases clipped lymph nodes exceeding or equaling 15, which were all testified by pathology. Contrast the variability of clinical pathobiology and corresponded regularity of lymph node metastasis between gastric superior part cancer and gastric inferior part cancer. Calculations were performed by statistical analysis.ResultsSignificantly differences were found in gender , tumor size, tumor site, histological grade, growth pattern, depth of invasion, serosa invaded and broken ends of fracture bone residual ect between upper stomach adenocarcinoma and lower gastric carcinoma (P<0.05), and had respective regular pattern of lymph node metastasis. But there was no significant correlation in total count and station of lymph node metastasis.ConclusionSignificantly differences were found in clinicopathological parameters and regular pattern of lymph node metastasis between upper stomach adenocarcinoma and lower gastric carcinoma. Malignantter biological behavivor was found in upper stomach adenocarcinoma. Compare with lower gastric carcinoma, tumor larger, infiltrating type growth, poor differentiation, easied serosa invaded and stage latter were found in gastric superior part cancer. This find testifies easied invation and extension with gastric inferior part cancer, not finding in aspect of lymph node metastasis, which possibly is the reason of poor prognosis for upper stomach adenocarcinoma.