Relationship Between The Expression Of The BRCA1 Protein And ER,C-erbB-2 Protein

ObjectiveTo explore the role of the breast cancer susceptibility gene BRCA1 in familial breast cancer and the relation between BRCA1 and ER,C-erbB-2 in breast cancer.MethodsThe levels of BRCA1 and ER, C-erbB-2 protein were detected by immunohisto-chemistry in 84 breast cancer paraffin-embeded blocks.Results1. The rate of BRCA1 expression in familial breast cancer and non-familial breast cancer was 69.0% and 9.5% respectively in the all case.2. The rate of ER expression in BRCA1 masculine expression breast cancer and BRCA1 negative expression breast cancer was 30.3% and60.8%. ER expression was significantly correlated with BRCA1 masculine expression. The rate of C-erbB-2 expression in BRCA1 masculine expression breast cancer and BRCA1 negative expression breast cancer was 36.3% and39.2%, C-erbB-2 expression was not significantly correlated with BRCA1 masculine expression .3. In familial breast cancer, the rate of ER expression in BRCA1 masculine expression breast cancer and BRCA1 negative expression breast cancer was 24.1% and30.7%. In familial breast cancer, the rate of C-erbB-2 expression in BRCA1 masculine expression breast cancer and BRCA1 negative expression breast cancer was 55.1% and46.1%.They have no correlated with BRCA1 masculine expression in familial breast cancer. 4. In non-familial breast cancer, the rate of ER expression in BRCA1 masculine expression breast cancer and BRCA1 negative expression breast cancer was 75.0% and65.7%. In non-familial breast cancer, the rate of C-erbB-2 expression in BRCA1 masculine expression breast cancer and BRCA1 negative expression breast cancer was 75.0% and60.5%.They have no correlated with BRCA1 masculine expression in non-familial breast cancer.ConclusionBRCA1 expression is high in familial breast cancer. It has relation to familial breast cancer. ER protein expression is low in BRCA1 mutations. BRCA1 expression has no relation to C-erbB-2 protein .It is great important to study the etiopathogenesis, early diagnosis, healing, prognostic evaluation in familial breast cancer.