The Clinical Observation And The Influence On SOD,VEGF,E₂,T Of Ruanmailing Koufuye On Vascular Dementia

Objective: Through the systematical clinical observation, the research appraisal theclinical curative effect of ruanmailing koufuye on vascular dementia,and investigatethe changes of SOD, VEGF, E₂, T, which provides the indexes for clinical treatmentof VaD.Methods:According to the NINDS-AIREN diagnosis criteria ,60 patients(28 femaleand 32 male) of VaD were selected,average age of 73.0±6.5 (60-85) .Then 60patients divided into two groups by the random way : Ruanmailing koufuyeGroup(treated group)30 cases,Sibohai Group(controlled group)30cases.The treatingmethod adopt sigle-blind way..Ruanmailing Group were given Ruanmailingkoufuye,PO,three times each day for 3months contiously.Sibohai Groupwere givenSibohai,po,only one each day for 3 months contiously.At the same time,30 healthyaged people were selected as a control average age of 70.2±7.2 (18 male and 12female,60～85years old).The plasma SOD level was determined by nitrate raductasecolorimetric,the serum E₂,T level were determined by radio immunoassay, and theplasma VEGF by enzyme linked immunosorbent double antibody method.Results: 1, The totle effective rate of Ruanmailing group was obvious.The resultshowed that the effect in the MMSE, ADL significently highly thanpretherapy(P＜0.05). 2.The SOD and VEGF level of VaD were significantly lowerthan those in the control (P＜0.05) .3. The surum E₂ level in the female patients of VaD were significantly lower than those in the female control (P＜0.05) .Nevertheless,theserum E₂ level in the male patients of VaD were significantly higher than those in thecontrol and the serum T level in the male patients of VaD were remarkable lower thanthose in the male control (P＜0.05) .4 The result showed that there was no significentdifference bewteen the Ruanmailing group and Sibohai group (P＞0.05)Conclusions: This finding indicated that Ruanmailing koufuye have significant use ofimproving light or midrange vascular demedntiao;including improving therapy effectand symptom of TCM,improving the ability of membering,language and cognitive.So the Ruanmailing koufuye which can nourish and supplement the liver andkidney, activate blood circulation to remove blood stasis has prevention and cure effecton VaD.