The Clinical Observation And The Influence On TXA₂,PGI₂,ET,HCY Of Ruanmailing Koufuye On Vascular Dementia

Vascular Dementia (VaD), represents various psychic dementia syndromewhich belongs to brain trauma caused by cerebrovascular disease.The research isguided by Chinese medicine science and based on experimental study ,to do theClinical observation of ruanmailing koufuye on Vascular Dementia.The conclusion ofthe research showed that ruanmailing koufuye has evident effects in curing VaD.Objective:Through the systematical clinical observation, the research appraisal theclinical curative effect and security of ruanmailing koufuye on vascular dementia,andinvestigate the changes of TXA₂,PGI₂,ET,HCY, which provides the indexes forclinical treatment of VaD.Methods:60 patient (28 female and 32 male,60～85years old)with VaD were chosenaccording to the diagnostic criteria and were divided into two groups by the randomand single-blind way :Ruanmailing Group(treated group)30cases,SibohaiGroup(controlled group)30cases.Ruanmailing Group were given Ruanmailingkoufuye,po,three times each day for 3months contiously.Sibohai Group were givenSibohai,po,only one each day for 3months contiously.At the same time,30 healthyaged people were selected as a control (18 male and 12 female,60～85years old).Theclinical curative effect and security of Ruanmailing were evaluated by the statisticsbased on the MMSE, ADL and the changes of TXA₂,PGI₂,ET,HCY.Results:1,The totle effective rate of Ruanmailing group was obvious.The resultshowed that the effect in the MMSE,ADL significently highly thanpretherapy(P＜0.05).2,The ET,TXA₂ and HCY level of VaD were significently higherthan those in the control (P＜0.01);the ET,TXA₂ and HCY level of pretherapy were significently higher than post-therapy (P＜0.01).3,The result showed that there was nosignificent difference bewteen the Ruanmailing group and Sibohai group (P＞0.05).Conclusions: The main pathogenic machanism of VaD is the yin-dificency of liverand kidney and the pathogenesis for qi deficiency and blood stasis. So the principaltreatment of VaD is to nourish and supplement the liver and kidney, activate bloodcirculation to remove blood stasis. Ruanmailing koufuye has notable,safe,reliableeffect on VaD.