The Study Of The Effect By Arterial Chemotherapy Embolization Of The Cervical Carcinoma And The Influence On Radical Hysterectomy

Objective:To explore and investigate the clinical therapeutic effect and the influence on radical hysterectomy of arterial chemotherapy embolization of the cervical carcinoma ofⅠB-ⅡB stage,and compared with radiotherapy group(R group).Methods:26 cases of mid-and advanced stages of cervical carcinoma at interventional ward from 2002.1～2006.12 were enrolled into the study and were treated with a 1-2 course of interventional therapy immediately after the pathological diagnosis,included 4 case ofⅠB 1,6 case ofⅠB2,6 case ofⅡA,10 case ofⅡB,Compared with the radiotherapy group that including 3 case ofⅠB1,8 case ofⅠB2,7case ofⅡA,8 case ofⅡB.Their therapeutic effect in the near future and the result of follow-up(included the influence on the radical excession,the side effects and the complications)were analyzed and compared,We analysed the data with statistics software of SPSS13.0.Results:Afer 1～2 times arterial chemotherapy embolization,26 cases occurred reversing in clinical stage(4 cases in stageⅠB1,6cases in stageⅠB2,6 cases in stageⅡA,10 cases in stageⅡB)and undergone radical hysterectomy with pelvic lymphadenectomy successfully,the tumor size apparently diminished,the scope of infiltrating cervix tissue were reduced and operation became easy.There is not significant difference was observed on the therapeutic effect rate and on the clinical symptoms released rate between the interventional group and the radiotherapy group.but with significant difference on complications,3 patients with radiation proctitis,3 patients with radiocystitis,6 patients with cervix tissue fibrosis(P＜0.05),compared to the radiotherapy group,stanched bleeding and alleviated the clinical symptom rapidly.the side effects were more(P＜0.01),nause,vomiting and leucopenia were vanished by curation and didn't affect following treatment of the patientsConclusion:Compared to radiotherapy,the intraarterial chemotherapy embolization of the uterine artery is one of the effective methods for treatment of cervical carcinoma.it can stop bleeding quickly;alleviate the clinical symptom rapidly,it can decrease the primary tumor size, improve local condition,prevent micrometastais to other organ,the tumor stage can be reversed, so that created surgical opportunity that enhanced the rate of removal of tumor,shorten operation time and reduced blood loss during the operation and less complication related to the chemotherapy or radical hysterectomy,apparently improved patient's survival quality.